The San Francisco 49ers face the Los Angeles Rams in their first divisional matchup. The 49ers are coming off a loss to the ...

NFL Network's Adam Rank on who stood out to him from New England Patriots and New York Jets and preseason hopefuls who have yet to deliver.

The San Francisco 49ers and Los Angeles Rams have aspirations of winning the NFC West and making another Super Bowl run, but ...

The 49ers are without Christian McCaffrey, Deebo Samuel and maybe George Kittle, while the Rams won’t have top receivers Cooper Kupp and Puka Nacua.

The San Francisco 49ers could be without another key offensive player this week after All-Pro tight end George Kittle missed ...

Injuries stacked up quickly for the San Francisco 49ers leading up to their Week 3 showdown with the Los Angeles Rams.

Josh Downs, who by all accounts was having a phenomenal training camp, is returning to the lineup in Week 3. He's been out since mid-August due to a high-ankle sprain. He's not projected to do a ton ...

The spread has moved one point in the Rams’ direction since Monday, likely because of the 49ers’ recent injury news ...

The first two weeks of the NFL season delivered plenty of unexpected chaos. Many were quick to overreact to Week 1 games, leading to several upsets in Week 2. C ...

Week 3 features some key games between 2-0 teams, including the Texans at the Vikings and the Chargers at the Steelers. And ...

Everything you need to know about the Rams' home game against the NFC West rival San Francisco 49ers, including start time, TV channel and betting odds.

Jimmy Garoppolo knows what it feels like as a San Francisco 49er to come to L.A., but now the quarterback is on the other ...