The San Francisco 49ers and Los Angeles Rams have aspirations of winning the NFC West and making another Super Bowl run, but both are dealing with significant losses on offense entering Week 3 when they go head-to-head.

The New York Giants enter Week 3 of the NFL season, still searching for their first win. For the eighth time in the last ten seasons, New York finds themselves in a 0-2 hole at the bottom of the NFC East that places an early dent in their aspirations of contending.

The Browns look to get over the .500 mark on Sunday with a home game against the winless New York Giants. Here's three big questions for the game.